Ultrasensitive, quantification of KIM-1 (Kidney Injury Molecule-1) is now available for the study and assessment of acute kidney injury (AKI) and chronic kidney disease (CKD).

Myriad RBM’s Ultrasensitive Simoa KIM-1 Immunoassay Testing Service
Plasma/Serum LLOQ = 3.10 pg/mL

KIM-1 is a biomarker of renal proximal tubular damage. Shedding of its extracellular domain into urine and blood is proportional to its cell surface expression levels. During KIM-1 upregulation, urine concentrations are higher than blood levels and as a result more sensitive than blood levels. However, with Myriad RBM’s Ultrasensitive Simoa KIM-1 assay, investigators can sensitively monitor KIM-1 in serum or plasma. KIM-1 testing from serum or plasma eliminates the need for urine collection, and avoids the confounding factors of variable protein concentrations in spot urine samples, or normalization to imperfect analytes such as urine creatinine. Recent research suggest that KIM-1 is not only a useful biomarker of AKI, but also an early indicator of CKD progression.

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Myriad RBM’s ultrasensitive KIM-1 testing is performed in our CLIA certified laboratory.

More on Myriad Simoa service:

Combine our growing menu of ultrasensitive Simoa assays with our comprehensive menu of multiplexed immunoassays to meet your drug development and human disease research needs.

Our CLIA certified immunoassay testing laboratory offers a service menu of nearly 300 protein biomarkers on our Multi-Analyte Profiling technology and 17 ultrasensitive Simoa assays.

NEW! Ultrasensitive AR and IL-31

Amphiregulin (AR) is a bi-functional growth-modulating member of the EGF family of growth factors and is a mitogen for fibroblasts, astrocytes, Schwann cells, and tumor cells. It can be a significant driver of breast cancer, in addition to various other cancers. It is also induced in inflammation, is pro-fibrogenic and has been linked to liver fibrosis, psoriasis, rheumatoid arthritis, and asthma.

Interleukin-31 (IL-31) is an important cytokine regulator of Th2 responses that is expressed predominantly by CD4+ T cells and mast cells. IL-31 is a biomarker for Atopic Dermatitis, as well as a therapeutic target for that and other skin diseases.

BIOMARKER	LLOQ (SERUM AND PLASMA)	LLOQ (UNDILUTED SAMPLES)	VOLUME REQUIRED
BIOMARKER	LLOQ (SERUM AND PLASMA)	LLOQ (UNDILUTED SAMPLES)	Serum or plasma	Other fluids
Amphiregulin (AR)	0.24 pg/mL	0.06 pg/mL	100 µL	150 µL
B Lymphocyte Chemoattractant (BLC, CXCL-13)	0.64 pg/mL	0.064 pg/mL	50 µL	150 µL
Granulocyte Colony-Stimulating Factor (G-CSF)	0.59 pg/mL	0.059 pg/mL	50 µL	150 µL
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)	0.036 pg/mL	0.009 pg/mL	100 µL	150 µL
Interferon alpha (IFN-alpha)	0.11 pg/mL	0.055 pg/mL	150 µL	150 µL
Interferon beta (IFN-beta)	0.16 pg/mL	0.04 pg/mL	100 µL	150 µL
Interferon gamma (IFN-gamma)	0.019 pg/mL	0.0095 pg/mL	150 µL	150 µL
Interleukin-1 beta (IL-1 beta)	0.0313 pg/mL	0.016 pg/mL	150 µL	150 µL
Interleukin-2 (IL-2)	0.050 pg/mL	0.025 pg/mL	150 µL	150 µL
Interleukin-5 (IL-5)	0.052 pg/mL	0.026 pg/mL	150 µL	150 µL
Interleukin-6 (IL-6)	0.091 pg/mL	0.0046 pg/mL	50 µL	150 µL
Interleukin-10 (IL-10)	0.0368 pg/mL	0.0092 pg/mL	100 µL	150 µL
Interleukin-12 Subunit p40 (IL-12p40)	7.300 pg/mL	0.730 pg/mL	50 µL	150 µL
Interleukin-17A (IL-17A)	0.048 pg/mL	0.012 pg/mL	100 µL	150 µL
Interleukin-31 (IL-31)	0.024 pg/mL	0.006 pg/mL	100 µL	150 µL
Kidney Injury Molecule-1 (KIM-1)	3.100 pg/mL	0.155 pg/mL	50 µL	150 µL
Tumor Necrosis Factor-alpha (TNF-a)	0.078 pg/mL	0.020 pg/mL	100 µL	150 µL

Check back often! We are continuously expanding our menu of high quality, Simoa-based immunoassays.

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