Llama IgG Fc Fusion Protein from ACROBiosystems

uniquely designed for llama immunization

In October 2017, Belgium-based pharmaceutical company Ablynx reported positive results for its first-in-class nanobody drug caplacizumab from a phase III trial on acquired thrombotic thrombocytopenic purpura (aTTP) patients. This success clearly proves the potential for nanobody drugs.

The general process for producing VHH includes the following steps:

ACROBiosystems provides a unique portfolio of llama lgG Fc tagged recombinant antigens. These products are uniquely designed for llama immunization with following characteristics:

· The llama lgG Fc can promote protein dimerization to enhance immunogenicity

· The tag has low immunogenecity

· Long half-life and good stability

· High purity (Fig 1)

· High activity (Fig 2)

· Low endotoxin (less than 10 EU/mg)

Product Features

Figure 1. Human PD-1, Llama IgG2b Fc Tag, low endotoxin (Cat. No. PD1-H5259) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

Figure 2. Immobilized Human BAFF, His Tag (Cat. No. BAF-H5248) at 5 ug/ml (100 uL/well) can bind Human BCMA, Llama IgG2b Fc Tag (Cat. No. BCA-H5259) with a linear range of 0.02-0.4 ng/mL (QC-tested).

Product list of proteins conjugated with llama lgG Fc tag - Exclusive

Molecule

Cat. No.

Product Description

BCMA

BCA-H5259

Human BCMA, Llama IgG2b Fc Tag, low endotoxin

CD19

CD9-H5250

Human CD19 (20-291), Llama IgG2b Fc Tag, low endotoxin

CD30

TN8-H5250

Human CD30, Llama IgG2b Fc Tag, low endotoxin

CD38

CD8-H5252

Human CD38, Llama IgG2b Fc Tag, low endotoxin

CD47

CD7-H5251

Human CD47, Llama IgG2b Fc Tag, low endotoxin

LAG-3

LA3-H525c

Human LAG-3, Llama IgG2b Fc Tag, low endotoxin

PD-1

PD1-H5259

Human PD-1, Llama IgG2b Fc Tag, low endotoxin

PD-L1

PDL-H5250

Human PD-L1, Llama IgG2b Fc Tag, low endotoxin

Siglec-2

SI2-H525a

Human Siglec-2, Llama IgG2b Fc Tag, low endotoxin

Siglec-3

CD3-H5259

Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin

Click to view all llama lgG Fc fusion proteins online

For subsequent biopanning of phage display library, we recommend the corresponding biotinylated proteins, which can be coated on Streptavidin-covered surface, for rapid high-throughput screening.

Product list of recommended biotinylated proteins

Molecule

Cat. No.

Product Description

BCMA

BC7-H82F0

Biotinylated Human BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)

CD30

CD0-H82E6

Biotinylated Human CD30 / TNFRSF8 Protein, Avi Tag (Avitag™)

CD38

CD8-H82E7