Tau proteins are primarily located in axons and stabilize microtubules in neurons.  In certain neurodegenerative diseases, known as tauopathies, tau becomes detached from microtubules and forms insoluble aggregates in the brain, known as neurofibrillary tangles (NFTs). Because tau can no longer stabilize microtubules in this form, and tau oligomers and tangles can be neurotoxic, neurons cease to function and die.

StressMarq now offers two monomers and two PFFs that allow scientists to induce and study this effect in vitro.  This gives them the potential to investigate the mechanisms of tau aggregation, the effect of various tau species on neurons, and ability of certain drugs to inhibit tau aggregation.

More Info




  1. Ozcelic, S. et al. Mol Psychiatry. 2016, 21(12): 1790–1798.
  2. alzforum.org/mutations/mutation-position-table/mapt-p301-mutations


Richiedi un'offerta

Via Umbria 10
20090 Segrate (Milano)

Tel. +39 02-26922300
Fax +39 02-26926058
Fax +39 02-26923535

If you no longer wish to receive these announcements click here