Pro5® MHC Class I Pentamers

ProT2® MHC Class II Tetramers

new products for understanding CD8+ and CD4+ T cell responses to CoVID-19/SARS-CoV-2

The following product range of CoVID-19/SARS-CoV-2-specific Pro5® Pentamers and ProT2® Tetramers for a range of published CD8+ and CD4+ T cell epitopes is available ordering immediately.

CoVID-19/SARS-CoV-2-specific Pro5® Class I Pentamers

Allele	Peptide Code	Peptide Sequence	Epitope Origin
A*02:01	4320	LLLDRLNQL	N protein 223-231
A*02:01	4321	FIAGLIAIV	S protein precursor 1202-1210
A*02:01	4322	ALNTLVKQL	S protein precursor 940-948
A*02:01	4323	LITGRLQSL	S protein precursor 978-986
A*02:01	4324	NLNESLIDL	S protein precursor 1174-1182
A*02:01	4326	VLNDILSRL	S protein precursor 958-966

CoVID-19/SARS-CoV-2-specific Pr oT2® Class II Tetramers

Allele	Peptide Code	Peptide Sequence	Epitope Origin
DRB1*01:01	4329	GAALQIPFAMQMAYRF	S protein 873-888
DRB1*01:01	4330	MAYRFNGIGVTQNVLY	S protein 884-899
DRB1*01:01	4331A	QLIRAAEIRASANLAATK	S protein 993-1010
DRB1*04:01	4332	QALNTLVKQLSSNFGAI	S protein 939-955
DRB1*04:01	4331B	QLIRAAEIRASANLAATK	S protein 993-1010

Advantages of Pro5® MHC Class I Pentamers

Pro5® MHC Pentamers

MHC Tetramers

Avidity &
configuration 5 MHC-peptide complexes per Pentamer in the same orientation result in enhanced avidity interaction with T cell receptor (TCR) MHC-peptide complex held in a tetrahedral configuration typically allowing only 3 MHC-peptide complexes to bind to TCRs

Brightness Unique labeling technology allows up to 5 fluorescent labels to attach to each Pentamer, yielding brighter signal By nature, tetramers will have one fluorescent label located at the center of the complex

Labeling flexibility Biotin-labeled Pentamers and unlabeled Pentamers, which can be labeled with the fluorochrome of choice, maximize the range of possible applications Tetramers, made by multimerizing biotinylated MHC monomers with fluorescent labeled streptavidin, must be supplied pre-labeled

Stability Unlabeled Pentamers can be stored long-term at -80°C and then used when required Tetramers incorporating a fluorochrome must be stored at 4°C, reducing their shelf life

Download Pentamer Handbook

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Advantages of Pro5® MHC Class I Pentamers
	Pro5® MHC Pentamers	MHC Tetramers
Avidity & configuration	5 MHC-peptide complexes per Pentamer in the same orientation result in enhanced avidity interaction with T cell receptor (TCR)	MHC-peptide complex held in a tetrahedral configuration typically allowing only 3 MHC-peptide complexes to bind to TCRs
Brightness	Unique labeling technology allows up to 5 fluorescent labels to attach to each Pentamer, yielding brighter signal	By nature, tetramers will have one fluorescent label located at the center of the complex
Labeling flexibility	Biotin-labeled Pentamers and unlabeled Pentamers, which can be labeled with the fluorochrome of choice, maximize the range of possible applications	Tetramers, made by multimerizing biotinylated MHC monomers with fluorescent labeled streptavidin, must be supplied pre-labeled
Stability	Unlabeled Pentamers can be stored long-term at -80°C and then used when required	Tetramers incorporating a fluorochrome must be stored at 4°C, reducing their shelf life