Introducing InVivoMAb anti-mouse CD96 (Clone 3.3) antibody reacts with CD96, also known as TACTILE (T cell activation increased late expression). CD96 is a type I transmembrane glycoprotein and member of the Ig superfamily. CD96 is expressed at low levels on resting NK cells and T cells and at high levels on activated NK and T cells. CD96 binds to its ligand, CD155 to mediate NK cell adhesion to target cells and cytotoxicity. CD96 has recently been identified as a novel target for cancer immunotherapy and has been shown to play a role in metastasis. The 3.3 antibody has been shown to suppress primary tumor growth in a number of experimental mouse tumor models. |