Neuropilin-1 and GDF-15
In addition to Myriad RBM’s InflammationMAP for COVID-19 research and therapy development, several more soluble protein biomarkers in our menu of 300+ biomarkers have recently been discovered to be extremely important in SARS-CoV-2 infection and pathologies.
Neuropilin-1
Two high profile papers published in Science1,2 demonstrate that Neuropilin-1 is a cell surface factor in addition to ACE2 for viral entry and infection. Blood levels of Neuropilin-1 may shed light on the importance of this factor.
GDF-15
A study in Circulation3 revealed that high baseline concentrations of GDF-15, a TGF-beta superfamily member with a role in inflammatory and apoptotic pathways, were associated with SARS-CoV-2 viremia and hypoxemia (both p<0.001) and was prognostically superior to established cardiovascular and inflammatory biomarkers.
IFN-a, IFN-ß, & IFN-?
Previous Science publications have also listed IFN-a, IFN-ß, & IFN-? ultrasensitive immunoassays as important markers for viral pneumonia, including COVID-19. You read can more in our blog post.
Publications
- Neuropilin-1 is a host factor for SARS-CoV-2 infection. (2020) Daly JL, et al. Science. DOI:10.1126/science.abd3072
- Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. (2020) Cantuti-Castelvetri L, et al. Science. DOI: 10.1126/science.abd2985
- Growth differentiation factor-15 provides prognostic information superior to established cardiovascular and inflammatory biomarkers in unselected patients hospitalized with COVID-19. (2020) Myhre PL, et al. Circulation. DOI: 10.1161/CIRCULATIONAHA.120.050360.
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