The World Health Organization (WHO) has declared the rise in mpox cases in the Democratic Republic of the Congo (DRC) and several other African countries as a Public Health Emergency of International Concern (PHEIC), under the International Health Regulations (2005).
Mpox, previously called monkeypox, is a viral disease that spreads primarily through close contact between people and, less commonly, via contaminated objects and surfaces. Symptoms include a rash lasting 2-4 weeks, often accompanied by fever, headache, muscle aches, back pain, fatigue, and swollen lymph nodes. Mpox is a highly contagious disease that can be fatal, with a mortality rate ranging from 0.1% to 10% among those infected. Newborns, children, pregnant individuals, and people with weakened immune systems, such as those with advanced HIV, are at a greater risk of severe illness and death from mpox.The Native Antigen Company offer a variety of antigens in support of mpox virus research.
Monkeypox virus (MPXV) is an enveloped double-stranded DNA virus, belonging to the genus Orthopoxvirus in the poxviridae family. Monkeypox virus has two different infectious virions: the intracellular mature virus (MV) and the extracellular enveloped viruses (EV). When the virus invades the host cell to complete the replication process, the MV cell surface binding protein E8L binds to the cell surface chondroitin sulfate, to provide viral particles attached to the target cell. A30L is also considered an important target in monkeypox virus research as an envelope protein for virus entry into a host and cell-cell fusion (syncytial formation). In addition, the envelope glycoprotein A35R on the surface of EV was predicted to affect the intercellular diffusion of virions. The combination of A29L with heparin on the cell surface promoted the fusion of viral membrane and host plasma membrane. Further, B21R, an important target protein with several key immuno-dominant epitopes, is the focus of monkeypox virus research.
HOT PRODUCTS: E8L, A30L, A35R, A29L, B21R
Abbexa is proud to offer an extensive range of products to support research into Mpox (Monkeypox)
Poxviruses are viruses from the Poxviridae family. This family of viruses includes several types of infectious viruses that affect both humans and animals. One of the most recognized viruses in Poxviridae is smallpox which has been mostly eradicated with the use of vaccines, while other viruses such as monkeypox have been spreading in countries around the world. Many viruses in the Poxviridae family have genetic similarities which allows many of the same research tools to be used on multiple viral species.
FEATURED PRODUCT
