Introducing Exazym®
Attomole-level detection of low-abundance biomarkers using standard ELISA workflows
 
Exazym® is a game-changing innovation in precision health that brings ultra-sensitive detection levels to conventional immunodiagnostic assays. 
Exazym® goal is to provide best-in-class sensitivity without propitiatory equipment or commitment to locked-in systems.
That’s why Cavidi has designed Exazym® as an add-on immunoassay reagent kit that requires no additional specialized equipment and can be easily added to existing immunoassay workflows.
Exazym® is based on a new detection method called Binding Oligo Ladder Detection, or BOLD for short.
This new amplification technique is ideally suited for detecting low-abundance analytes.
It offers up to 100x signal amplification gains and 50x lower limit of detection.

The BOLD Science Behind Exazym®
Binding Oligo Ladder Detection (BOLD)

How BOLD Works
 
At the heart of Exazym® is BOLD (Binding Oligo Ladder Detection), a new detection technology based on well-established science.
A primer conjugated to the secondary antibody works with polymerase to create a long ladder of poly BrdU:rA hybrid strand to which tertiary antibodies with reporter molecules selectively bind.
This is how BOLD amplifies immunoassay signals by up to 100 times.
The technology is broadly applicable for immunoassays and independent of instrument platforms.
The amplification step works at ambient temperature or at 37°C.
 
Ideal for Detecting Low-Abundance Biomarkers
 
• Up to 100x signal amplification and 50x lower limit of detection
• Compatible with standard ELISA equipment and protocols
• Minimal extension of assay time
• Retain validated antibody pairs
• Consistent results across multiple runs and samples
• High sensitivity, specificity, repeatability, and accuracy

Ultra-Sensitivity that’s Ultra-Practical

Many potential biomarkers exist at levels below the detection limits of current techniques, posing challenges for research as well as clinical and diagnostic applications across medical specialties.
 While a number of ultra-sensitive proprietary systems have emerged in recent years, they typically require specialized instrumentation, software, and new protocols.
This elevates costs and introduces logistical complexities that hinder adoption on a large scale.
Exazym® overcomes these challenges by offering researchers attomolelevel detection using standard immunoassay workflows and equipment.
 
 
Are you looking for more information about Exazym?
Come and meet us at XXII Convention Telethon in Rimini
 
 
 
DBA-ITALIA Srl
Via Umbria 10
20054 Segrate (Milano)
Tel. +39 02-26922300

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