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Gene Link is the leader in triple repeat disorder genotyping using non-radioactive based methods. Gene Link has more than a decade of expertise and has developed facile non-radioactive detection methods for safe, sensitive and reliable genotyping of human genetic disorders.
The gene detection systems product line is divided into four broad groups based on detection methods:
- Genemer Products (specific primer pairs for mutation specific amplification)
- PCRProber Products (PCR + Southern Blot chemiluminescent detection)
- GeneProber Products (Southern Blot non-radioactive genotyping detection system)
- GScan Products (Amplification reagents)
- Genemer Control DNA
GENEPROBER as rapid, reliable and sensitive as 32P labeled southern blots. No more decayed probes and radioactive exposure.
A specific gene fragment probe for Southern blot based hybridization of genomic DNA. The GeneProberTM is available unlabeled for radioactive based methods and labeled with digoxigenin for chemiluminescent detection. One tube is supplied containing 500 ng of the lyophilized unlabeled GeneProberTM probe and the quantity supplied is sufficient for at least 5 random prime labeling reactions.
The GeneProberTM product line is based on the chemiluminescent Southern blot detection method. These probes are specially developed to detect the triple repeat amplifications. Fragile X, Huntington disease, Myotonic dystrophy, Friedreich's ataxia and Kennedy disease GeneProberTM unlabeled and digoxigenin labeled are available.
Best Seller: Fragile X Syndrome
Fragile X syndrome is the most common form of inherited mental retardation. It affects approximately 1 in 1200 males and 1 in 2500 females. As suggested by the name, it is associated with a fragile site under specific cytogenetic laboratory conditions at position Xq27.3
Fragile X genotyping can be done by direct PCR amplification of the CGG trinucleotide repeats region or by southern analysis.
Gene Link offers safe and reliable chemiluminescent detection methods as an alternate to radioactive based detection methods. PCR-Prober™, GScan™ and GeneProber™ line of products replaces radioactive based methods. Gene Link’s GScan Ver2 kit is for PCR amplification followed by fluorescent detection of the specific triple repeat fragment size and routinely detects greater than 120 CGG repeats.
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Tel. +39 02-26922300
Fax +39 02-26926058
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