KITS: ELISA, RAPID TESTS, RT-PCR, ASSAY

ELISA

• WS-1096 Wantai SARS-CoV-2 Ab ELISA 96 wells, CE-IVD (2)
• WS-1196 Wantai SARS-CoV-2 IgM ELISA 96 wells, CE-IVD (3)

RAPID TEST

• WJ-2750 WANTAI SARS-CoV-2 Ab Rapid Test 50tests, CE-IVD (4)

RT-PCR

• WS-1248 Wantai SARS-CoV-2 RT-PCR Kit 48 test IVD (5)

• RC311-C1
• CD302-02
• C6603C-02

Assay Genie | New COVID19 QPCR Triplex Detection Kit

• 1 Step RT-PCR kit
• Simultaneous detects 2 X 2019-CoV2 genes & internal control (RNP) genes
• Also includes positive control and RTase control
• 100 reaction pack size
• Research-Use-Only

ELISA Genie | Tocilizumab ELISA & ADA Kits

Recently, the FDA approved a Phase III clinical trial for the use of Tocilizumab (Actemra) in severe COVID19 patients. These are highly sought after kits at the moment.

New Tocilizumab ELISA and ADA kits

• Detects free drug or ADA in serum/plasma
• Human, NHP, Mouse, rat
• Sensitivity 10ng/ml

Assay Genie | COVID19 Rapid Tests | Detect COVID19 in 15 minutes

The new COVID19 Rapid test is the latest in testing technology and allows for the detection of novel Coronavirus in 15 minutes with 10ul blood

Key Features

• Detects IgG and IgM to 2019-nCoV in 15 minutes
• 10ul blood or 20ul serum/plasma required
• Room temperature storage
• CE IVD certified

ELISA KITS Targets in Virus Infection

• SEB886Hu - ELISA Kit for Angiotensin I Converting Enzyme 2 (ACE2)
• SEB540Hu - ELISA Kit for Cluster Of Differentiation 147 (CD147)
• SEC795Hu - ELISA Kit for Transmembrane Protease, Serine 2 (TMPRSS2)

Also available ELISA Targets in Cytokine Storm. (Proteins and antibodies also available).

Since there is no approved treatment for infection with the 2019-nCoV /SARS-CoV-2 virus, the causative agent of the COVID-19 pandemic these two kits have been designed to screen for inhibition of binding between the ACE2 protein found on the surface of target pneumocytes, and the Spike glycoprotein that extends from the viral envelope

ACE2:SARS-CoV-2 Spike Inhibitor Screening Assay Kit #79936

SARS-CoV-2 Spike:ACE2 Inhibitor Screening Assay Kit #79931

The kits have similar design, with either ACE2 or the Spike protein bound to an ELISA plate, followed by incubation with the test inhibitor. Labeled Spike or ACE2 protein is added, followed by detection with HRP-labeled antibody and a chemiluminescent substrate. The kits are available in either format, to provide flexibility in experimental design, and to help find selective inhibitors that bind to either the Spike or ACE2 proteins, respectfully.

ACE2 Inhibitor Screening Assay Kit, #79923

The expression levels of ACE2 may affect the severity of coronavirus infections, and ACE inhibitors have been shown to decrease the risk of pneumonia. The ACE2 Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity

Note that BPS also offers Coronavirus Screening Services using these 3 kits.

There is no effective treatment for COVID-19 in the market. It is urgent to develop the 2019-nCoV inhibitors, for example vaccines, therapeutic antibodies and small molecular compounds against COVID-19. ACRO has developed the 2019-nCoV inhibitor screening kit based on the biotinylated ACE2 protein and 2019-nCoV S protein RBD. This inhibitor screening ELISA pair is designed to facilitate the identification and characterization of 2019-nCoV inhibitors.

ANTIBODIES

A snippet from our infectious disease product range

In response to the Coronavirus COVID-19 pandemic, ProSci Inc has developed and manufactured COVID-19 (SARS-CoV-2, 2019-nCoV) antibodies and research reagents against the virus. Polyclonal antibodies and monoclonal antibodies are available for order against COVID-19 virus SARS-CoV-2 spike, envelope, and nucleocapsid protein. More polyclonal, monoclonal, and recombinant single domain antibodies are currently in our antibody production pipeline.

Find out products here

For COVID-19(SARS-CoV-2) receptor reagents, check out our ACE2 products

• Anti-SARS-CoV S Antibody CR3022 for ELISA MRO-1214LC
• Anti-SARS-CoV S Antibody 80R for ELISA MRO-693LC
• Anti-SARS-CoV S Antibody S109.8 for ELISA MRO-692LC
• Anti-SARS-CoV S Antibody S230.15 for ELISA MRO-691LC
• Anti-SARS-CoV S Antibody S227.14 for ELISA MRO-690LC
• Anti-SARS-CoV S Antibody 508-573 for ELISA, WB MRO-689LC
• Anti-SARS-CoV S Antibody 512-9 for ELISA, WB MRO-688LC
• Anti-SARS-CoV S Antibody 73-121 for ELISA, WB MRO-677LC
• Anti-SARS-CoV S Antibody S104.1 for ELISA MRO-614LC
• Anti-SARS-CoV S Antibody 12-28-1 for ELISA, WB MRO-676LC
• Anti-SARS-CoV S Antibody S103.3 for ELISA MRO-613LC
• Anti-SARS-CoV S Antibody SC03-007 for ELISA MRO-700LC
• Anti-SARS-CoV S Antibody S101.1 for ELISA MRO-611LC

More products available here

PROTEINS/INHIBITORS

SARS-CoV-2—Promising Antiviral Agents

MedChemExpress Anti-COVID-19 Compound Library based on Relevant Proteins :

We conduct Virtual Screening of approved compound library and clinical compound library based on 3CLpro (PDB ID: 6LU7), RdRp, Spike Glycoprotein (PDB ID: 6VSB), nsp15 (PDB ID: 6VWW), PLpro and ACE2 Structure.

Partial Screening Library Data:

Trimer Structure S Protein Verified by SEC-MALS

An article published in Science determined a 3.5-angstrom-resolution cryo-electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. To facilitate medical countermeasure development, ACROBiosystems has developed the full length S protein with a trimer structure. The molecular weight and polymer form of the protein was verified by SEC-MALS technology. Also offered high quality 2019-nCoV S1, S RBD, N, human ACE2 and other proteins. The bioactivity was verified by SPR and BLI.

Lectins from various sources have been shown to exhibit potent antiviral properties by inhibiting infection of clinically important viral pathogens. The antiviral activity of lectins is largely attributed to direct binding to viral envelope glycans and preventing entry of the virus into cells.

Vector Laboratories is an established manufacturer of many plant lectins that are described in the literature as valuable tools in ongoing research to elucidate their potential in suppression of viral activity. Below is a list of mannose-specific and mannose/glucose-specific lectins, available in unconjugated and conjugated formats.

• Galanthus nivalis
• Hippeastrum hybrid
• Narcissus pseudonarcissus
• Concanavalin A
• Lens culinaris
• Musa paradisiaca
• Pisum sativum

Based on prior studies on coronaviruses such as SARS-CoV and MERS-CoV, mannose-specific plant lectins can be used to investigate antiviral properties of the novel coronavirus SARS-CoV-2, the virus that causes COVID-19.

BPS also provides a number of recombinant proteins for coronavirus research:

• ACE2 protein, #11003 ACE2 is the cellular receptor for several coronaviruses, including human respiratory coronavirus NL63, the SARS-coronavirus (SARS-CoV) and the novel coronavirus 2019-nCoV/SARS-CoV-2.
• 2019-nCoV Spike, RBD #100687 and 2019-nCoV Spike S1 #100688 The Spike protein mediates viral entry into host cells by binding to ACE2 through the receptor-binding domain (RBD) in the S1 subunit and then fusing the viral and host membranes through the S2 subunit. BPS offers both the full S1 subunit or just the RBD region.
• PLPro protein, #81091 PLPro is the Papain-Like Protease encoded by the SARS-coronavirus (SARS-CoV). It downregulates interferon production, leading to increased pathogenesis.
• PLP2 protein, #81090 The NL63 coronavirus genome encodes two papain like proteases, PLP1 and PLP2. PLP2 downregulates the innate immune response to NL63 via disruption of the STING pathway
• 14-3-3theta, #79038 14-3-3 theta has been observed to mediate nucleo-cytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) of the SARS-coronavirus (SARS-CoV).

Pro5® MHC Class I Pentamers

ProT2® MHC Class II Tetramers

New products for understanding CD8+ and CD4+ T cell
responses to CoVID-19/SARS-CoV-2

The following product range of CoVID-19/SARS-CoV-2 specific  Pro5® Pentamers  and  ProT2® Tetramers  for a range of published CD8+ and CD4+ T cell epitopes is available ordering immediately.

CoVID-19/SARS-CoV-2-specific Pro5® Class I Pentamers

CoVID-19/SARS-CoV-2-specific ProT2® Class II Tetramers